Manager, R&D Finance at Definium Therapeutics

<div class="content-intro"><p>Definium Therapeutics&nbsp;is a late-stage clinical biopharmaceutical and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.&nbsp;&nbsp;</p> <p>Our lead&nbsp;product&nbsp;candidate,&nbsp;lysergide&nbsp;tartrate&nbsp;(our&nbsp;proprietary orally disintegrating tablet form of&nbsp;lysergide&nbsp;(LSD) D-tartrate),&nbsp;represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p> <p>Guided by&nbsp;the recognition&nbsp;that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address&nbsp;the&nbsp;underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.&nbsp;</p> <p>Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!</p></div><p>Reporting to the Director, Finance, the <strong>Manager, R&amp;D Finance</strong> will support end‑to‑end financial management of the Company’s research and development activities, with a primary focus on clinical trial accounting, accruals, budgeting, and financial controls. This role will be responsible for ensuring the timely and accurate preparation of R&amp;D‑related accounting data, specifically site payments and accruals, and will partner closely with the Clinical Operations and Development teams to provide financial insight, support decision‑making, and maintain strong internal controls.</p> <p>The Manager, R&amp;D Finance will play a key role in monthly close activities, clinical expense forecasting, audit support, and process improvement initiatives, while collaborating cross‑functionally with Clinical Operations, Legal, Procurement, FP&amp;A, and external vendors.</p> <p><strong>Responsibilities:</strong></p> <p><strong>Clinical &amp; R&amp;D Accounting</strong></p> <ul> <li>Prepare and review month‑end accruals related to clinical trials, CROs, sites, and other R&amp;D vendors</li> <li>Maintain recurring journal entries and supporting documentation related to R&amp;D expenses</li> <li>Apply accounting judgment related to the timing and recognition of clinical trial costs</li> <li>Prepare quarterly clinical vendor confirmations and audit support schedules</li> </ul> <p><strong>Clinical Trial Financial Oversight</strong></p> <ul> <li>Validate monthly site payments and partner with the Company’s site payment vendor to resolve discrepancies</li> <li>Review and analyze Clinical Trial Agreements (CTAs), amendments, and site budgets (including Phase 3 trials) for financial accuracy and alignment with forecasts</li> <li>Track clinical milestones, pass‑through costs, and vendor commitments to ensure accurate expense recognition</li> </ul> <p><strong>Budgeting, Forecasting &amp; Analysis</strong></p> <ul> <li>Perform detailed monthly actual‑versus‑budget variance analysis for R&amp;D and Clinical Operations spend</li> <li>Maintain rolling forecasts for clinical trial expenses and support updates based on study progress, amendments, and vendor activity</li> <li>Assist with the annual budget and periodic forecast processes, including scenario analysis related to clinical timelines and spend variability</li> </ul> <p><strong>Cross‑Functional Partnership</strong></p> <ul> <li>Serve as a key finance partner to Clinical Operations and Development teams, translating clinical activity into financial impacts</li> <li>Coordinate with Legal and Procurement on contract economics, payment terms, and amendments</li> <li>Collaborate with FP&amp;A to align accounting data with forecasts, cash runway analyses, and management reporting</li> </ul> <p><strong>Controls, Audit &amp; Process Improvement</strong></p> <ul> <li>Assist with the design, execution, and documentation of Sarbanes‑Oxley (SOX) controls related to R&amp;D and clinical accounting</li> <li>Serve as a primary finance contact for internal and external audit requests related to clinical and R&amp;D spend</li> <li>Identify and implement process improvements to enhance accuracy, efficiency, and scalability of R&amp;D financial processes</li> </ul> <p><strong>Other</strong></p> <ul> <li>Support special projects, system enhancements, and ad hoc analyses as needed</li> <li>Perform other general accounting duties as assigned</li> </ul> <p><strong>Minimum Qualifications</strong></p> <ul> <li>Bachelor’s degree in Accounting, Finance, or related field; CPA preferred</li> <li>Minimum of 5 years of progressive accounting or finance experience; public company experience strongly preferred</li> <li>Experience supporting R&amp;D and/or clinical trial accounting within the life sciences industry strongly preferred</li> <li>Demonstrated ability to apply accounting judgment in areas involving estimates, accruals, and complex contracts</li> <li>Experience with NetSuite or other ERP systems; advanced Excel skills required</li> <li>Strong analytical, organizational, and problem‑solving skills</li> <li>Ability to manage multiple priorities and meet deadlines in a fast‑paced environment</li> <li>Strong communication skills and ability to work effectively with non‑finance stakeholders</li> </ul> <p></p> <p>The starting base pay range for this position is $111,365.00 - $135,356.00. Compensation will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location.</p> <p>Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including:</p> <ul> <li>100% paid health benefits including Medical, Dental and Vision for you and your dependents</li> <li>401(k) program with company match and vesting after the turn of the first month after your start date</li> <li>Flexible time off</li> <li>Generous parental leave and some fun fringe perks!</li> </ul> <p></p>