Research Associate / Sr. Research Associate – T-Cell Engineering and Gene Editing (CONTRACT) at Addition Therapeutics

<p><strong>Company&nbsp;</strong></p> <p>Addition Therapeutics is at the forefront of biotechnology innovation, advancing transformative therapies utilizing its proprietary PRINT™ (Precise RNA-mediated Insertion of Transgenes) platform. PRINT™ redefines genetic medicine by enabling development of RNA-only therapeutics capable of inserting any genetic element into specific safe harbor sites within the genome. Operating from state-of-the-art labs in South San Francisco, our team of experienced scientists and drug developers is leading scientific breakthroughs while cultivating a vibrant, dynamic culture committed to profoundly impacting patient lives.</p> <p><strong>Job description</strong></p> <p>Addition Therapeutics is seeking a researcher with experience in T cell engineering and gene editing, either in industry or an academic setting. This individual would have experience in both primary lymphocyte/PBMC culture and assays required to characterize edited T cells.</p> <p><strong>About the Role</strong><br>The day-to-day responsibilities of this role will include:</p> <ul> <li>Execution of experiments involving lymphocyte engineering, gene editing, immunology, synthetic biology, molecular biology, and cell biology.</li> <li>Collaborating on team projects.</li> <li>Communicating, documenting, and presenting work.</li> </ul> <p><strong>Qualifications&nbsp;</strong></p> <p>Required:</p> <ul> <li>Bachelors Degree in Molecular and Cell Biology, Bioengineering, Immunology, or related fields with 3+ years experience engineering T cells in industry or academia.</li> <li>Experience in primary human T cell and PBMC culture and engineering.</li> <li>T cell functional assays (e.g. cytotoxicity, exhaustion, activation)</li> <li>Experience in multi-color flow cytometry, DNA and RNA readout methods (ddPCR, RT-PCR, etc), and culture of cell lines.</li> <li>Hands-on experience with <em>in vivo</em> models of CAR T cell efficacy and safety studies</li> <li>Organized, motivated, and disciplined when it comes to hands-on work in the lab</li> <li>Excellent oral and written communication skills</li> <li>Thrives in a fast-moving, results-oriented startup environment</li> <li>Flexible, cooperative, can-do attitude</li> </ul> <p>Preferred</p> <ul> <li>Experience in non-viral gene delivery</li> <li>RNA delivery and expression of transgenes</li> <li>Experience in RNA synthesis and purification by in vitro transcription</li> </ul> <p><strong>Compensation</strong></p> <p>The expected hourly rate for this position is $55.00-$60.00 / hour. Exact compensation may vary based on skills and experience.</p> <p>We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.</p>