Senior Research Associate (Contractor) at Freenome

<p><strong>About this opportunity:</strong><strong><br></strong></p> <p><span style="font-weight: 300;">At Freenome, we are seeking a Senior Research Associate to help grow our Genomics Assay Development team. At Freenome, you will help develop the assay technologies used to analyze patient samples and contribute to our mission of early cancer detection. The ideal candidate will work to develop assay technologies for our multiomic platform manually and on robotic platforms. You will develop, characterize, verify, and validate clinical-grade assays to measure complex, blood-based analytes (e.g., whole-genome sequencing of cfDNA). You will work cross-functionally with Research &amp; Development teams, automation and process engineering, computational science, and clinical operations to develop and transfer NGS-based assays in a regulated, high-throughput environment. You are passionate about developing life saving diagnostics using NGS technologies, and you will have a significant impact on the continued growth of an organization dedicated to changing the entire landscape of cancer.</span></p> <p><span style="font-weight: 300;">The role reports to the Manager of Genomics Late Stage Development. This role will be an onsite role based in our Brisbane, California headquarters.&nbsp;</span></p> <p><strong>What you’ll do:</strong></p> <ul> <li style="font-weight: 300;"><span style="font-weight: 300;">Apply knowledge of molecular biology, nucleic-acid biochemistry, and next-generation sequencing to develop assays for DNA, including genome-wide and targeted approaches<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Participate in experimental design and independently plan and execute mission-critical experiments to optimize and characterize assay performance<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Create and manipulate high impact assay inputs, including use of biological samples and formulation of contrived samples and reagents as required<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Gather high-quality data, take detailed notes, and openly communicate on lessons learned while performing experiments<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Perform data analysis, create summary presentations, and present results cross-functionally<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Perform technical troubleshooting, identify and implement process improvements across the lab by thinking critically about the execution of all experiments<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Build productive working relationships and collaborate with engineers and clinical laboratory members to transition development protocols into clinical production, including automation, validation experiments, and SOP development<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Contribute to writing study protocols and reports. Diligently apply current Good Laboratory and Documentation Practices (cGLP, cGDP)<br></span></li> </ul> <p><strong>Must haves:</strong></p> <ul> <li style="font-weight: 300;"><span style="font-weight: 300;">Bachelor’s or Master’s degree in molecular biology, biochemistry, genetics, or a related field with at least 4 years of professional experience in the life sciences. Prior experience in clinical diagnostics and/or working in a start-up environment is preferred&nbsp;<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Experience executing verification and validation studies for IVD assays in a regulated laboratory environment (GLP)<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Hands-on experience in Next-gen sequencing (NGS) based assay development including extraction, library preparation, target capture, and sequencing&nbsp;<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Familiarity with molecular biology, genomics, NGS, assay development, sample preparation, reagent handling, or related laboratory workflows (e.g. plasma separation processes, DNA/RNA extraction, purification, and quantification, NGS library preparation)<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Experience designing, planning, and executing successful experiments, interpreting results, preparing data for review, and giving effective scientific presentations<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">High attention to detail and ability to record accurate and detailed observations, assess impact, and perform troubleshooting as required<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Ability to manually pipette with high confidence, accuracy, and precision<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Clear and proactive communication skills and ability to collaborate effectively with team members in the same and adjacent disciplines<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Strong organizational skills and the ability to contribute the design and implementation of new processes<br></span></li> <li style="font-weight: 300;"><span style="font-weight: 300;">Flexible and highly motivated to learn new skills and comfortable adapting to changing priorities<br></span></li> </ul> <p><strong>Nice to haves:</strong></p> <ul> <li><span style="font-weight: 300;">Experience in working with with methylated ctDNA/cfDNA as an analyte in liquid biopsy workflows </span></li> <li><span style="font-weight: 300;">Experience with automated liquid handlers, laboratory information systems, sample tracking systems, and equipment scheduling/status tools</span></li> <li><span style="font-weight: 300;">Familiarity with programing in a scientific programming language (e.g., Python or R)<br></span></li> </ul> <p><strong>Additional information:</strong></p> <p><span style="font-weight: 300;">Contractors may be hired through a third-party provider and will be considered contingent workers. </span><span style="font-weight: 300;">We invite you to check out our career page @ <em><a href="http://freenome.com/job-openings/" target="_blank" data-saferedirecturl="https://www.google.com/url?q=http://freenome.com/job-openings/&amp;source=gmail&amp;ust=1708620295766000&amp;usg=AOvVaw0K-a4lTJ0RquYagpqS-yp4">freenome.com/job-openings/</a></em> </span><span style="font-weight: 300;">for additional company information.&nbsp;&nbsp;</span></p> <p><span style="font-weight: 300;">Freenome is proud to be an equal opportunity employer and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local </span><span style="font-weight: 300;">law.</span></p> <p><em><span style="font-weight: 300;">Applicants have rights under Federal Employment Laws.&nbsp;&nbsp;</span></em></p> <ul> <li><span style="font-weight: 300;"><em><a href="https://www.dol.gov/agencies/whd/posters/fmla" target="_blank"><em><span style="font-weight: 300;">Family &amp; Medical Leave Act (FMLA)</span></em></a></em></span></li> <li><span style="font-weight: 300;"><em><a href="https://www.dol.gov/agencies/ofccp/posters" target="_blank"><em><span style="font-weight: 300;">Equal Employment Opportunity (EEO)</span></em></a></em></span></li> <li><span style="font-weight: 300;"><em><a href="https://www.dol.gov/agencies/whd/posters/employee-polygraph-protection-act" target="_blank"><em><span style="font-weight: 300;">Employee Polygraph Protection Act (EPPA)</span></em></a></em></span></li> </ul> <p><span style="color: #ecf0f1;"><em><span style="font-weight: 300;">#LI-ONSITE</span></em></span></p>