Bio-Analytical Co-op-Northeastern Students at Seaport Therapeutics

<p>Seaport Therapeutics is a clinical-stage&nbsp;therapeutics&nbsp;company advancing the development of novel neuropsychiatric medicines in areas of high unmet patient needs. The Company has a proven strategy of advancing clinically validated mechanisms previously held back by limitations that are overcome with its proprietary&nbsp;GlyphTM technology platform. All the therapeutic candidates in its pipeline of first and best-in-class medicines are based on the Glyph platform, which is uniquely designed to enable oral bioavailability, bypass first-pass&nbsp;metabolism&nbsp;and reduce hepatotoxicity and other side effects. Seaport is led by an experienced team that invented and advanced important neuropsychiatric medicines and&nbsp;are&nbsp;guided by an extensive network of renowned scientists,&nbsp;clinicians&nbsp;and key opinion leaders. For more information, please visit <a href="https://www.seaporttx.com/">www.seaporttx.com</a>.&nbsp;</p> <p><strong>Job Description</strong></p> <p>Seaport Therapeutics is seeking a co-op student for a lab-based bioanalysis position to be part of our Discovery team. This co-op will have a focus on LC-MS to assist in the screening of novel drugs. We are looking for a highly motivated individual who is looking to be a part of a multidisciplinary team and to gain experience in a startup environment. This position will contribute to advancing the pipeline of impactful candidates generated from our novel Glyph™ prodrug platform.</p> <p>Some of the responsibilities will include:</p> <ul> <li>Executing <em>in vitro </em>experiments, using LC-MS, for the screening of lipid prodrugs to support preclinical discovery</li> <li>Processing and analyzing <em>in vivo</em> samples (plasma, lymph fluid, etc.) to generate DMPK data for various prodrugs</li> </ul> <ul> <li>Contributing to the development and optimization of LC-MS methods for both quantitative and qualitative analysis</li> <li>Routine use and troubleshooting of LC-MS instrumentation</li> <li>Documenting all experiments using an electronic notebook and analyzing data for reports and regular internal presentations</li> </ul> <p><strong>Experience and Skills</strong></p> <ul> <li>&nbsp;Enrolled in a Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, or related program at the Master’s Level</li> <li>Previous Co-op or lab experience is preferred</li> <li>Knowledge of or experience with: HPLC, reverse phase chromatography, mass spectrometry instrumentation, enzyme kinetics, protein precipitation, liquid-liquid extraction</li> <li>Strong organizational skills, attention to detail, and eagerness to learn.</li> </ul>