Principal Scientist, Chemical Development at Immunome, Inc.
Bothell, Washington, United StatesFull-timeTech OperationsPosted about 2 months ago
Apply with PipelineAbout the Role
<div class="content-intro"><p><strong><u>Company Overview</u></strong></p>
<div class="x_elementToProof" data-olk-copy-source="MessageBody">
<div data-olk-copy-source="MessageBody">Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.</div>
</div></div><p><span style="text-decoration: underline;"><strong><span data-contrast="auto">Position Overview</span></strong></span></p>
<p><span data-contrast="auto">We are seeking an experienced Principal Scientist, Chemical Development to join our dynamic team to help advance our pipeline of innovative targeted cancer therapies. The successful candidate will apply their expertise in small molecule process development and manufacturing to support a variety of modalities in the Immunome pipeline with a focus on small molecule linker-payload targets for ADCs. This person will play a key role in leading challenging drug candidate process development programs, enabling treatment of patients in need.</span><span data-ccp-props="{"201341983":0,"335559740":257}"> </span></p>
<p><span style="text-decoration: underline;"><strong><span data-contrast="auto">Responsibilities</span></strong></span></p>
<p><strong><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Leadership</span></span></strong><span data-ccp-props="{"335559739":0}"> </span></p>
<ul>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Provide technical leadership as a key member of the chemical development team while </span><span data-ccp-parastyle="No Spacing">maintaining</span><span data-ccp-parastyle="No Spacing"> alignment with the company's goals and </span><span data-ccp-parastyle="No Spacing">objectives</span><span data-ccp-parastyle="No Spacing">. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Function as the technical lead on at least one program while also functioning as an individual technical contributor. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Provide guidance and leadership to external partners working towards the successful advancement of antibody drug conjugates, radiopharmaceuticals, and other lead programs. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Support programs at the bench as an individual contributor as needed. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
</ul>
<p><strong><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Technical Expertise</span></span></strong><span data-ccp-props="{"335559739":0}"> </span></p>
<ul>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Leverage knowledge and experience in the development and execution of robust and scalable small molecule synthetic processes. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Devise and evaluate alternative routes of synthesis with the aim of developing robust and efficient routes to APIs while reducing cost of goods (COGs) and shortening manufacturing lead times. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Develop robust data packages for technical transfer of processes for manufacturing partners at external CMOs. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Maintain knowledge of the current state of the art in synthetic methods </span><span data-ccp-parastyle="No Spacing">utilized</span><span data-ccp-parastyle="No Spacing"> for the construction of complex molecules. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Carry out thorough analytical data collection both as an individual contributor in the lab as well as via oversight and review of data collected at our external partners</span><span data-ccp-parastyle="No Spacing">. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Contribute to authoring relevant sections of various regulatory documents (IND, IMPD, NDA, briefing books, etc.) and provide SME support for related regulatory inquiries. </span></span><span data-ccp-props="{"335559739":0}"> </span><span data-ccp-parastyle="No Spacing"> </span><span data-ccp-props="{"335559685":720,"335559739":0}"> </span></li>
</ul>
<p><strong><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Cross-Functional Collaboration </span></span></strong><span data-ccp-props="{"335559739":0}"> </span></p>
<ul>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Execute the integrated CMC regulatory strategies for pipeline programs. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Collaborate with research, regulatory affairs, and CMC teams to ensure seamless coordination of activities. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Provide feedback to research on synthetic routes and raw materials that are CMC friendly.</span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Foster strong collaborations with internal and external stakeholders. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="11" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Engage colleagues in discovery chemistry to provide CMC input of target molecules under evaluation for future development. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
</ul>
<p><span data-contrast="auto"><span data-ccp-parastyle="No Spacing"> </span></span> <strong><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Innovation</span></span></strong><span data-ccp-props="{"335559739":0}"> </span></p>
<ul>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="16" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Stay abreast of the latest advancements in synthetic </span><span data-ccp-parastyle="No Spacing">methodology</span><span data-ccp-parastyle="No Spacing"> as well as </span><span data-ccp-parastyle="No Spacing">new technologies</span><span data-ccp-parastyle="No Spacing"> and methodologies to enhance our capabilities.</span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="16" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Advance Immunome’s intellectual property portfolio. </span></span><span data-ccp-props="{"335559739":0}"> </span><span data-ccp-parastyle="No Spacing"> </span><span data-ccp-props="{"335559685":720,"335559739":0}"> </span></li>
</ul>
<p><strong><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Quality and Compliance</span></span></strong><span data-ccp-props="{"335559739":0}"> </span></p>
<ul>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="18" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Ensure compliance with relevant regulatory guidelines and industry standards for chemical development processes. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="18" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Uphold high-quality standards and address any compliance issues.</span></span> </li>
</ul>
<p><span style="text-decoration: underline;"><strong><span data-contrast="auto">Qualifications</span></strong></span></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559683":0,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">PhD in Synthetic Organic Chemistry or similar</span><span data-ccp-parastyle="No Spacing"> wit</span><span data-ccp-parastyle="No Spacing">h a </span><span data-ccp-parastyle="No Spacing">m</span><span data-ccp-parastyle="No Spacing">inimum of 7 years of industry experience leading small molecule and/or linker-payload programs</span><span data-ccp-parastyle="No Spacing">,</span><span data-ccp-parastyle="No Spacing"> or equivalen</span><span data-ccp-parastyle="No Spacing">t combination of education and experience. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559683":0,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Experience as a technical lead overseeing tech transfer, process </span><span data-ccp-parastyle="No Spacing">development</span><span data-ccp-parastyle="No Spacing"> and implementation of processes for manufacture at internal and/or external manufacturers is a plus.</span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559683":0,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Occasional evening and/or weekend commitment.</span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="" data-font="Symbol" data-listid="3" data-list-defn-props="{"335552541":1,"335559683":0,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Ability to travel domestically and internationally (5-15%).</span></span><span data-ccp-props="{"335559739":0}"> </span></li>
</ul>
<p><span data-contrast="auto"><span data-ccp-parastyle="No Spacing"> </span></span> <span style="text-decoration: underline;"><strong><span data-contrast="auto">Knowledge and Skills</span></strong></span></p>
<ul>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="23" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Ability to design cost effective robust manufacturing processes for complex small molecule targets as well as troubleshoot and solve complex technical challenges quickly. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="23" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Brings a collaborative and open-minded attitude when working with various internal and external teammates. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="23" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Meticulous and detail-oriented scientist with the ability to </span><span data-ccp-parastyle="No Spacing">operate</span><span data-ccp-parastyle="No Spacing"> as an individual contributor at the bench while also managing external partners. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="23" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Proficient in generating robust and reliable analytical data </span><span data-ccp-parastyle="No Spacing">utilizing</span><span data-ccp-parastyle="No Spacing"> various technologies in a hands-on capacity as well as evaluation of analytical data generated at external partners. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="23" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Proficient in </span><span data-ccp-parastyle="No Spacing">writing</span><span data-ccp-parastyle="No Spacing"> technical reports and formulating presentations </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="23" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Ability to develop cross functional relationships with discovery chemistry and other pre-clinical groups. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="23" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Experience in leading and managing technology transfers to </span><span data-ccp-parastyle="No Spacing">third party</span><span data-ccp-parastyle="No Spacing"> process development and manufacturing partners. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="23" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Knowledge of cGMP requirements and ICH guidelines related to CMC small molecule drug-substance development and manufacturing.</span><span data-ccp-parastyle="No Spacing"> </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="23" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Track record</span><span data-ccp-parastyle="No Spacing"> of working closely with cross-functional teams in a biopharmaceutical or pharmaceutical environment. </span></span><span data-ccp-props="{"335559739":0}"> </span></li>
<li data-leveltext="·" data-font="Symbol" data-listid="1" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"·","469777815":"hybridMultilevel"}" data-aria-posinset="23" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Excellent interpersonal and communication skills.</span></span><span data-ccp-props="{"335559739":0}"> </span></li>
</ul>
<p><span data-ccp-props="{}"> </span></p><div class="content-pay-transparency"><div class="pay-input"><div class="title">Washington State Pay Range</div><div class="pay-range"><span>$169,593</span><span class="divider">—</span><span>$206,233 USD</span></div></div></div><div class="content-conclusion"><p><strong><u>E/E/O</u></strong></p>
<p>Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.</p>
<p><strong><u>E-Verify</u></strong></p>
<p>Immunome, Inc. is a participant in E-Verify. Please review the following notices: <a href="https://immunome.box.com/s/bopxukipfidxjscs4bjxt75f90bvpppk" target="_blank">E-Verify Participation Poster</a> | <a href="https://immunome.box.com/s/r51g9subw1wqni9xkutbl6up635sjr8e" target="_blank">Right to Work Poster (English)</a> | <a href="https://immunome.box.com/s/r3ekbimwh988my9vzl76tnlbg60zvh9u" target="_blank">Right to Work Poster (Spanish)</a>.</p></div>
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