Associate Scientist, Antibody Sciences at Immunome, Inc.
Bothell, Washington, United StatesFull-timeResearchPosted 8 days ago
Apply with PipelineAbout the Role
<div class="content-intro"><p><strong><u>Company Overview</u></strong></p>
<p></p>
<div class="x_elementToProof" data-olk-copy-source="MessageBody">Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been submitted to the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-3050, an IND-cleared FAP-targeted radiotherapy; and IM-1617, an IND-cleared solid tumor ADC. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.</div></div><p><span style="text-decoration: underline;"><strong><span data-contrast="auto">Position Overview</span></strong></span></p>
<p><span data-contrast="auto">Immunome is seeking a highly motivated and detail-oriented Associate Scientist, Antibody Sciences to drive our in-house high-throughput (HTP) recombinant protein production efforts, spanning protein expression, purification, and characterization through basic screening in support of rapid, data-driven protein engineering and discovery workflows.</span><span data-ccp-props="{}"> </span></p>
<p><span data-contrast="auto">This position will leverage analytical methods including SEC-UPLC, HIC-UPLC, DLS, reduced mass spectrometry, and biolayer interferometry (BLI) to characterize key properties of generated molecules and inform iterative protein engineering. </span><span data-ccp-props="{}"> </span></p>
<p><span data-contrast="auto">A key function of this role will be overseeing the integrity and management of Immunome’s recombinant antibody and protein inventory, from intake through material distribution across the organization, enabling efficient iteration and seamless execution across the R&D team.</span><span data-ccp-props="{}"> </span></p>
<p> </p>
<p><span style="text-decoration: underline;"><strong><span data-contrast="auto">Responsibilities</span></strong></span></p>
<p><strong><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Research Design and Execution</span></span></strong><span data-ccp-props="{"201341983":0,"335559731":360,"335559739":0,"335559740":240}"> </span></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Recombinant protein production, including high-throughput transient expression and purification.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Execute analytical assays including SEC-UPLC, HIC-UPLC, DLS, and reduced mass spectrometry.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Perform mammalian tissue culture in support of recombinant protein production.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Perform BLI-based assays, including single-point (yes/no) binding and full kinetic binding.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Maintain strong attention to detail and record keeping for inventory management of recombinant proteins.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="6" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Apply understanding of molecular biology and protein structure, including principles relevant to antibodies.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<p><span data-ccp-props="{"201341983":0,"335559685":720,"335559739":0,"335559740":240}"> </span></p>
<p><strong><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Data Analysis and Interpretation</span></span></strong><span data-ccp-props="{"201341983":0,"335559731":360,"335559739":0,"335559740":240}"> </span></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="7" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Analyze and summarize experimental data from protein production, characterization, and binding assays.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="8" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Interpret results and communicate implications to support iterative protein engineering and discovery workflows.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<p><span data-ccp-props="{"201341983":0,"335559685":720,"335559739":0,"335559740":240}"> </span></p>
<p><strong><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Project Collaboration</span></span></strong><span data-ccp-props="{"201341983":0,"335559731":360,"335559739":0,"335559740":240}"> </span></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="9" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Collaborate with colleagues across biology, chemistry, pharmacology, and translational medicine to achieve project goals.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="10" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Organize and share data to enable efficient collaboration with other research teams.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<p><span data-ccp-props="{"201341983":0,"335559685":720,"335559739":0,"335559740":240}"> </span></p>
<p><strong><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Documentation and Reporting</span></span></strong><span data-ccp-props="{"201341983":0,"335559731":360,"335559739":0,"335559740":240}"> </span></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="11" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Maintain detailed and </span><span data-ccp-parastyle="No Spacing">accurate</span><span data-ccp-parastyle="No Spacing"> electronic laboratory notebooks documenting experimental procedures, results, and conclusions.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="12" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Prepare and present research findings to internal teams and contribute to project updates and strategic discussions.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<p><span data-ccp-props="{"201341983":0,"335559685":720,"335559739":0,"335559740":240}"> </span></p>
<p><strong><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Continuous Learning and Development</span></span></strong><span data-ccp-props="{"201341983":0,"335559731":360,"335559739":0,"335559740":240}"> </span></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="13" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Stay informed about the latest advancements in techniques for producing and characterizing protein therapeutics.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="10" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="14" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Proactively seek opportunities for professional development and contribute to the scientific growth of the research team.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<p><span data-ccp-props="{"201341983":0,"335559685":720,"335559739":0,"335559740":240}"> </span></p>
<p><span style="text-decoration: underline;"><strong><span data-contrast="auto">Qualifications</span></strong></span></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="23" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Bachelor’s degree in molecular biology, biochemistry, biophysics, immunology, or related </span><span data-ccp-parastyle="No Spacing">field</span><span data-ccp-parastyle="No Spacing">s</span><span data-ccp-parastyle="No Spacing">.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="23" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">3</span><span data-ccp-parastyle="No Spacing"> year</span><span data-ccp-parastyle="No Spacing">s</span><span data-ccp-parastyle="No Spacing"> of lab experience in preclinical drug development in the biotechnology or pharmaceutical industry</span><span data-ccp-parastyle="No Spacing">, or equivalent.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="23" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Strong understanding of molecular biology and protein sciences.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="23" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Experience with mammalian tissue culture.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="23" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Experience with </span><span data-ccp-parastyle="Normal (Web)">Octet</span><span data-ccp-parastyle="Normal (Web)"> or similar instrument is a plus.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="23" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="6" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Experience with antibody discovery workflows is a plus.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="23" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="7" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Familiarity with </span><span data-ccp-parastyle="Normal (Web)">Benchling</span><span data-ccp-parastyle="Normal (Web)"> is a plus.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></li>
</ul>
<p> </p>
<p><span style="text-decoration: underline;"><strong><span data-contrast="auto">Knowledge and Skills</span></strong></span></p>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="16" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Hands-on experience with recombinant protein expression and purification in high-throughput workflows.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="16" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Experience applying biophysical and analytical characterization methods (SEC-UPLC, HIC-UPLC, DLS, reduced mass spectrometry).</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="16" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Working knowledge of BLI/Octet assay setup, execution, and data interpretation.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="16" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Strong laboratory skills in mammalian cell culture and sample handling for protein production.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="16" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Ability to analyze data, summarize results, and communicate findings to cross-functional teams.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="16" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="6" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Excellent documentation practices, including electronic laboratory notebooks and organized data management.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="16" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="7" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">High attention to detail and strong organizational skills, including inventory management and sample tracking.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="16" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="8" data-aria-level="1"><span data-contrast="auto"><span data-ccp-parastyle="No Spacing">Ability to work effectively in a fast-paced, collaborative research environment and adapt to changing priorities.</span></span><span data-ccp-props="{"201341983":0,"335559739":0,"335559740":240}"> </span></li>
</ul><div class="content-pay-transparency"><div class="pay-input"><div class="title">Washington State Pay Range</div><div class="pay-range"><span>$87,143</span><span class="divider">—</span><span>$102,002 USD</span></div></div></div><div class="content-conclusion"><p><strong><u>E/E/O</u></strong></p>
<p>Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.</p>
<p><strong><u>E-Verify</u></strong></p>
<p>Immunome, Inc. is a participant in E-Verify. Please review the following notices: <a href="https://immunome.box.com/s/bopxukipfidxjscs4bjxt75f90bvpppk" target="_blank">E-Verify Participation Poster</a> | <a href="https://immunome.box.com/s/r51g9subw1wqni9xkutbl6up635sjr8e" target="_blank">Right to Work Poster (English)</a> | <a href="https://immunome.box.com/s/r3ekbimwh988my9vzl76tnlbg60zvh9u" target="_blank">Right to Work Poster (Spanish)</a>.</p></div>
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