Research Associate/Senior Research Associate, In Vivo Pharmacology at Manifold Bio

<div><strong>Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems.</strong><span style="color: #262626;"> Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works</span><span style="color: #262626;">&nbsp;across this full stack to pursue programs both internally and with leading pharma companies.</span></div> <p><strong>Position</strong></p> <p>We are seeking a highly-motivated In Vivo Pharmacology Senior Research Associate&nbsp; who thrives in a fast-paced and creative environment to push the capabilities of our multiplexed<em> in vivo</em> drug discovery platform. Together with senior researchers, you will play a critical role in executing <em>in vivo</em> studies to support internal research projects. This is a hands-on role and you should have extensive experience in multiple aspects of <em>in vivo</em> pharmacology including dosing, necropsy, perfusion, tissue collection and&nbsp; sample processing, among others. The ideal candidate must be able to work effectively both in a collaborative setting and independently.&nbsp;</p> <p><strong>Responsibilities</strong></p> <ul> <li>Conduct in vivo mouse studies, including dosing via IV, IP, SQ, and other routes as needed.</li> <li>Perform necropsy, tissue dissection, perfusion, and blood/tissue collection (in-life and terminal</li> <li>Perform blood collections via submandibular cheek bleeds and cardiac punctures.</li> <li>Prepare and process tissues for downstream analysis.</li> <li>Accurately label samples, track collection, and maintain comprehensive records.</li> <li>Follow protocols rigorously and contribute to protocol refinement when needed.</li> <li>Ability to follow SOPs and work independently in a high-throughput setting.</li> <li>Maintain accurate and organized data entry and analysis.</li> <li>Collaborate with cross-functional teams in a dynamic research environment.</li> <li>Strong attention to detail with excellent data organization and recordkeeping.</li> <li>Assist in maintaining inventories.</li> </ul> <p><strong>Required Qualifications</strong></p> <ul> <li>Bachelors or Masters and 1-2+ years of experience (biotech/pharma industry preferred) in executing in vivo pharmacology experiments in mice</li> <li>Demonstrated expertise executing hands-on <em>in vivo</em> studies</li> <li>Collaborative, curious, and flexible with strong communication skills, both written and oral</li> <li>Self-motivated, highly organized,&nbsp; able to work independently with minimal supervision, and able to multitask</li> <li>Strong attention to detail</li> <li>A genuine passion for science and developing medicines</li> </ul> <p><strong>Preferred Qualifications</strong></p> <ul> <li>Familiarity with histology, microscopy, or tissue sectioning</li> <li>Experience in bioanalytical assays for protein therapeutics (PCR, nucleic acid extraction, ELISA, Western Blot, etc)</li> <li>Skilled with common data analysis and productivity software such as Microsoft Office, GraphPad Prism, and ImageJ.</li> <li>Experience&nbsp; writing detailed research project plans and methodological SOPs that guide yours and other team members’ laboratory activities</li> <li>Experience in mouse health monitoring is highly preferred</li> </ul> <p><strong>Base Salary Range: </strong>$70,000-108,000</p> <p>This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.</p> <p>This role is eligible for:</p> <ul> <li>Annual performance-based target bonus</li> <li>Stock options</li> <li>Comprehensive medical, dental, and vision coverage</li> <li>401(k) plan</li> <li>Flexible paid time off and holidays</li> <li>Perks including on-site gym, onsite lunch, and commuter support</li> </ul> <p>Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.</p><div class="content-conclusion"><p><em style="color: rgb(34, 34, 34); font-family: Arial, Helvetica, sans-serif; font-weight: 400; letter-spacing: normal; text-align: start; white-space: normal; word-spacing: 0px; text-decoration: none;"><em><span style="font-weight: 400;">We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.</span></em></em></p></div>