Clinical Trial Leader at Tango Therapeutics

<p><span style="font-family: helvetica, arial, sans-serif;"><strong>Company Overview</strong></span></p> <p><span style="font-family: helvetica, arial, sans-serif;">Tango Therapeutics is a biotechnology&nbsp;company&nbsp;dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.</span></p> <p><span style="font-family: helvetica, arial, sans-serif;">Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.</span></p> <p><span style="font-family: helvetica, arial, sans-serif;">This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.</span></p> <p><span style="font-family: helvetica, arial, sans-serif;">The Tango labs and offices are located at&nbsp;201 Brookline Avenue, in&nbsp;the Fenway area of Boston, Massachusetts.</span></p> <p style="text-align: justify;"><span style="font-family: helvetica, arial, sans-serif;"><strong>Summary&nbsp;</strong></span></p> <p style="text-align: justify;"><span style="font-family: helvetica, arial, sans-serif;">We are seeking a Clinical Trial Leader (CTL) to lead cross-functional clinical trial teams (CTTs) in the execution of clinical trials of Tango’s portfolio. This role will chair the CTT and represent the cross-functional team to internal governance bodies. The CTL will be an internal escalation point for other CTT members.</span></p> <p style="text-align: justify;"><span style="font-family: helvetica, arial, sans-serif;">In a fast-paced, small biotech environment, the CTL will operationally lead the set-up, conduct and reporting of clinical trials as per approved timelines, budget, regulatory requirements, and internal standards. This individual will play a key role in the execution and delivery of clinical trial objectives.</span></p> <p style="text-align: justify;"><span style="font-family: helvetica, arial, sans-serif;">The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.</span></p> <p><span style="font-family: helvetica, arial, sans-serif;"><strong>Your role</strong></span></p> <ul> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Lead cross-functional Clinical Trial Team (CTT) in the planning, execution, and reporting of outsourced clinical trial.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Provide regular updates to internal governance bodies.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Serve as the primary liaison between the sponsor and CRO to ensure alignment of trial objectives, timelines, and deliverables.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Oversee CRO performance, ensuring adherence to scope, budget, and timelines.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Contribute to protocol development and review of key study documents (e.g., ICFs, CRFs, monitoring plans).</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Lead the development of trial-specific plans including risk management, communication, and oversight plans.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Support site selection and feasibility assessments in collaboration with CRO and internal stakeholders.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Monitor trial progress through metrics and KPIs.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">In collaboration with Operational Excellence and Compliance, define an optimal RBQM framework to efficiently control quality throughout the trial.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Proactively identify risks and issues and support the development and implementation of mitigation strategies and action plans.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Ensure timely delivery of trial milestones including patient recruitment, data collection, and interim analyses.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Manage trial budgets, change orders, and invoice reconciliation in collaboration with vendor management and finance.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Ensure study conduct in compliance with ICH GCP, ISO standards, regulatory requirements, and internal standards.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Participate in audits and inspections. Ensure timely resolution of findings.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Review and approve essential documents and study deliverables.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Oversee database lock, clinical study report (CSR) development, and study close-out activities.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Contribute to regulatory submissions and responses as needed.</span></li> </ul> <p><span style="font-family: helvetica, arial, sans-serif;"><strong>What You Bring</strong></span></p> <ul> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">8+ years of trial management experience with 3+ years in trial leadership position.Bachelor’s degree in Life Sciences, Pharmacy or related field (required).</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Advanced degree, e.g., MS, PharmD, PhD, MBA (preferred).</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Experience working in global clinical development organization.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Experience in Oncology development (preferred).</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred).</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Experience in outsourcing and oversight.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Knowledge of ICH GCP, FDA guidelines, EU CTR and other relevant guidelines.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Knowledge of financial planning, tracking, and reporting.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Knowledge of trial risk assessment and management.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and operational metrics, KPIs, and KRIs.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Strong vendor management and project management skills.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Excellent leadership skills with the ability to lead cross-functional teams.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Strong interpersonal and communication skills.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Strong analytical thinking and decision-making capabilities.</span></li> <li style="font-family: helvetica, arial, sans-serif;"><span style="font-family: helvetica, arial, sans-serif;">Willingness to travel, as required (typically 10–20%)</span></li> </ul> <p style="text-align: center;"><span style="font-family: helvetica, arial, sans-serif;"><em style="text-align: center;">We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.</em></span></p> <p style="text-align: center;">&nbsp;</p> <p>&nbsp;</p> <p><span style="color: rgb(255, 255, 255); font-family: helvetica, arial, sans-serif;">#LI-Hybrid</span></p> <p>&nbsp;</p><div class="content-pay-transparency"><div class="pay-input"><div class="title">Salary range </div><div class="pay-range"><span>$160,000</span><span class="divider">&mdash;</span><span>$241,000 USD</span></div></div></div>